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At 645, we partner with relentless founders who defy convention to change the future. See all our portfolio companies →

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Portfolio

GoldbellyGoldbelly

Goldbelly snags $100M after 300% growth

SetpointSetpoint

A16Z leads $43M Series A for Setpoint

ResidentResident

Resident gets unicorn sized exit

RentSpreeRentSpree

RentSpree celebrates 2 Million users milestone

OvertimeOvertime

Overtime Raises $100M Series D

Panther LabsPanther Labs

Panther raises at a $1.4B valuation

LunchboxLunchbox

Lunchbox Raises $50M Series B

FiscalNoteFiscalNote

FiscalNote went public on Monday, August 1, 2022

Shift5Shift5

“World’s Most Innovative Companies of 2024” -Fast Company

How we help

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Customer Acquisition & Retention

“When the COVID-19 Pandemic hit, small businesses like Squire’s customer base of barbershops were left particularly vulnerable. 645 rolled up their sleeves and quickly got to work helping us design a PPP solution for our customers and connecting us with key government officials to help guide reopening policies and set new safety standards.”

Talent & Advisors

“645 Ventures has been instrumental in helping ECL go from 0 to 1 since Day 1, supporting our growth in every funding round. Beyond being an equity partner, 645 has provided valuable strategic insights and helped us hire world-class talent across various functions. As we prepare for the next stage of growth, they continue to support us by leveraging their network and providing subject matter experts to help expand our team.”

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Fundraising & Round Structuring

“The 645 Team has been with us since our seed round and provided invaluable support over the course of our Series A & Series B fundraising processes. From brainstorming the right valuation and pitch prep to term negotiations, 645’s partnership alleviated some of the pressure so we could focus on what matters.”

Community News

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Articles

What We’re Watching: 645 Ventures’ Inflections and Predictions for 2026What We’re Watching: 645 Ventures’ Inflections and Predictions for 2026
What We’re Watching: 645 Ventures’ Inflections and Predictions for 2026
December 30, 2025
Shop Circle raises $60MShop Circle raises $60M
Shop Circle raises $60M
February 26, 2025
Team of Female Founders is Overhauling AI ProtectionTeam of Female Founders is Overhauling AI Protection
Team of Female Founders is Overhauling AI Protection
February 25, 2025
Cube raises $25MCube raises $25M
Cube raises $25M
Just Raised
July 6, 2024
10 Years On, 645 Ventures Is Using Software To Improve Its Odds At Seed10 Years On, 645 Ventures Is Using Software To Improve Its Odds At Seed
10 Years On, 645 Ventures Is Using Software To Improve Its Odds At Seed
Major Announcement
July 3, 2024
Overtime named Time Magazine’s 100 Most Influential Companies for ‘24Overtime named Time Magazine’s 100 Most Influential Companies for ‘24
Overtime named Time Magazine’s 100 Most Influential Companies for ‘24
Major Announcement
May 31, 2024
Ashley and Resident Announce AcquisitionAshley and Resident Announce Acquisition
Ashley and Resident Announce Acquisition
Major Announcement
March 3, 2024
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