Investment Areas

Where We Invest

Seven areas of deep domain experience where we back founders from the earliest days.

645's Investment Size by Stage
$1 — $5M
Seed
$5 — $10M
Series A
$5 — $15M
Growth and late stage
Enterprise

Enterprise is one of our core investment areas, where we focus on backing infrastructure platforms that power large, fragmented industries. We are particularly drawn to verticalize

4
Investors
20
Founders
9
Companies
Deep Tech

Deep Tech is another core area of focus, where we invest in companies building foundational technologies that reshape critical industries and national capabilities. Our portfolio i

2
Investors
12
Founders
6
Companies
AI Infra / DevTools

We focus on investing in the critical layers that power how software is built, deployed, and scaled. In late 2025, AI agents got coherent enough to build software largely on their

3
Investors
13
Founders
6
Companies
Fintech

Fintech is a core area of our investment strategy, where we focus on companies that modernize financial services, insurance, and risk management through technology. Our portfolio t

3
Investors
21
Founders
10
Companies
Consumer

Consumer is a core pillar of our strategy. We pay close attention to technology inflections — moments when new capabilities either open up services that were never accessible to mo

2
Investors
37
Founders
17
Companies
Cybersecurity

Cybersecurity is a key focus area for our investments, where we target companies building advanced defenses and intelligence platforms that protect critical digital infrastructure.

1
Investor
11
Founders
6
Companies
Health Tech

Health Tech is a core area of investment, focused on companies that leverage technology to transform care delivery, diagnostics, and patient engagement. Our portfolio supports solu

1
Investor
10
Founders
5
Companies